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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PIAS1 All Species: 13.64
Human Site: S510 Identified Species: 30
UniProt: O75925 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75925 NP_057250.1 651 71836 S510 S P V S R T P S L P A V D T S
Chimpanzee Pan troglodytes XP_523109 766 83908 S625 S P V S R T P S L P A V D T S
Rhesus Macaque Macaca mulatta XP_001082800 642 70843 L502 P V S R T P S L P A V D T S Y
Dog Lupus familis XP_535524 651 71773 S510 S P V S R T P S L P A V D T S
Cat Felis silvestris
Mouse Mus musculus O88907 651 71599 S510 S P V S R T P S L P A V D T S
Rat Rattus norvegicus O70260 628 68345 G488 S K G A L T S G H Q P S S V L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516107 756 82793 R609 H Q A S P V S R T P S L P A V
Chicken Gallus gallus NP_001026627 564 62782 E424 R S K K E V Q E V T T S Y N G
Frog Xenopus laevis NP_001079161 649 71676 P509 A S P I S R T P S L P P V D S
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q94361 793 89556 K603 K T P P Q Q K K K T K D D D I
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q680Q4 884 97015 I538 G Y Q E K N I I P M S S S A T
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 84.9 98.6 99.6 N.A. 98 58.6 N.A. 82.2 82.9 87 N.A. N.A. N.A. N.A. 24 N.A.
Protein Similarity: 100 84.9 98.6 99.8 N.A. 98.7 72 N.A. 84.2 85 94.3 N.A. N.A. N.A. N.A. 40.9 N.A.
P-Site Identity: 100 100 0 100 N.A. 100 13.3 N.A. 13.3 0 6.6 N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: 100 100 6.6 100 N.A. 100 20 N.A. 26.6 6.6 13.3 N.A. N.A. N.A. N.A. 13.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 20 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 35.9 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 10 10 0 0 0 0 0 10 37 0 0 19 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 19 46 19 0 % D
% Glu: 0 0 0 10 10 0 0 10 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 10 0 10 0 0 0 0 10 0 0 0 0 0 0 10 % G
% His: 10 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % H
% Ile: 0 0 0 10 0 0 10 10 0 0 0 0 0 0 10 % I
% Lys: 10 10 10 10 10 0 10 10 10 0 10 0 0 0 0 % K
% Leu: 0 0 0 0 10 0 0 10 37 10 0 10 0 0 10 % L
% Met: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 10 0 0 0 0 0 0 0 10 0 % N
% Pro: 10 37 19 10 10 10 37 10 19 46 19 10 10 0 0 % P
% Gln: 0 10 10 0 10 10 10 0 0 10 0 0 0 0 0 % Q
% Arg: 10 0 0 10 37 10 0 10 0 0 0 0 0 0 0 % R
% Ser: 46 19 10 46 10 0 28 37 10 0 19 28 19 10 46 % S
% Thr: 0 10 0 0 10 46 10 0 10 19 10 0 10 37 10 % T
% Val: 0 10 37 0 0 19 0 0 10 0 10 37 10 10 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 10 0 0 0 0 0 0 0 0 0 0 10 0 10 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _